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Tetrahydrocannabinol (THC)

Tetrahydrocannabinol (THC) is the principal psychoactive and most renowned ingredient in marijuana and, depending on the particular plant, either THC or cannabidiol (CBD) is the most abundant cannabinoid in marijuana.

First discovered by Israeli Scientists in the early 1960’s, THC is the most researched, analysed and effective cannabinoid in the spectrum and has been attributed therapeutic value in over 30 ailments:

-A 1996 study revealed that THC can halt the development of certain tumours, through the initiation of cell death.

-In 2006, a study revealed that THC, along with endogenous cannabinoids can stimulate appetite, making it an ideal therapeutic alternative for anorexia, cachexia and bulimia.

-A recent study indicated that THC can help with pain relief. THC blocks pathways through the central nervous system, systematically preventing pain signals from the brain.

-A 1998 study revealed that THC reduced intraocular pressure in Glaucoma patients by up to 65%. However, the effects were short lived and would be impossible to continue without the risk of systemic toxic effects. Scientists are working on a way to prolong the reduced pressure.

-A study by the University of Illinois indicated that THC can stabilises autonomic output during sleep, reduces spontaneous sleep-disordered breathing, and blocks serotonin-induced exacerbation of sleep disorders such as sleep apnea.

-A study published by the Virginia Commonwealth University suggested that THC binding onto CB-1 receptors can reduce the duration and seriousness of seizures in epileptic test models.

– A 2006 study in the Journal of Molecular Pharmaceutics, concluded that THC inhibits enzymes that are key pathological markers in the development of Alzheimers.

Official Research Reports

Proof of concept trial of dronabinol in obstructive Sleep Apnea. (Prasad B, Radulovacki MG, Carley DW, 2013)

Medical marijuana use for chronic pain: risks and benefits. (Greenwell GT, 2012)

A Molecular Link between the Active Component of Marijuana and Alzheimer’s Disease Pathology (Lisa M. Eubanks, Claude J. Rogers, 2006)

Endocannabinoids, feeding and suckling–from our perspective. (Mechoulam R, Berry EM, Avraham Y, Di Marzo V, Fride E, 2006)

Marijuana Smoking vs Cannabinoids for Glaucoma Therapy. (Green K, 1998)

NTP Toxicology and Carcinogenesis Studies of 1-Trans-Delta(9)-Tetrahydrocannabinol (CAS No. 1972-08-3) in F344 Rats and B6C3F1 Mice (Gavage Studies). (National Toxicology Program, 1996)

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