Project Description

What are CB-2 Receptors?

Discovered in 1993 by researchers at Cambridge University looking for a second receptor that could explain the therapeutic properties of THC, the CB-2 Receptor has since played a vital role in scientific study on the importance of the endocannabinoid system and its agonists.

Despite being closely related to its CB-1 counterpart, CB-2 receptors do not transmit as efficiently to the brain as CB-1 receptors, although have still been known to play a role in modulating neurological disorders. Instead, CB-2 receptors are concentrated predominantly in peripheral organs; most commonly the immune system, the gastrointestinal system and the peripheral nervous system.

Scientific investigations have indicated that CB-2 receptors are prevalent throughout the tissues of the immune system. The receptors have been found to regulate the release of cytokines; proteins that control the development and receptiveness of cell populations that respond to infection or inflammation.

CB-2 receptors have also been discovered in the peripheral nervous system, where they have the ability to mediate palliative effects.

Perhaps the most significant discovery regarding the functions of CB-2 receptors is their ability to control inflammation in the gastrointestinal system, making their cannabinoid agonists a genuine therapeutic option for diseases such as Crohn’s or IBS.

Despite CB-1 receptors playing a far more important role in brain function than its counterpart, CB-2 receptors have nonetheless been discovered in the brain. While CB-1 receptors work in conjunction with neurons, CB-2 receptors work specifically with Microglia cells, whose primary function is to control immune defense in the nervous system.

The visual below indicates the primary functions of CB-2 Receptors in the human body.


Official Research Reports

Activation of Cannabinoid Type Two Receptors Diminish Inflammatory Responses in Macrophages and Brain Endothelium. (Persidsky Y, 2015)

Cannabinoid Receptor CB2 Is Involved in Tetrahydrocannabinol-Induced Anti-Inflammation against Lipopolysaccharide in MG-63 Cells. (Yang L, 2015)

Is lipid signaling through cannabinoid 2 receptors part of a protective system? (P. Pacher, 2011)

Cannabinoids and intestinal motility: welcome to CB2 receptors (Angelo A Izzo, 2004)

Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer’s disease brains. (Benito C, 2003)