Project Description

Definition

acute-glaucoma (1)Glaucoma is a term describing a group of ocular (eye) disorders resulting in optic nerve damage or loss to the field of vision, in many patients caused by a clinically characterized pressure buildup in regards to the fluid of the eye (intraocular pressure-associated optic neuropathy).

In a large number of glaucoma patients, however, the intraocular pressure (IOP) is normal, i.e. below 20 mm Hg. These patients display the same signs of glaucomatous damage as those with an elevated IOP; their condition is thus called normal tension glaucoma. The disorders can be roughly divided into two main categories, “open-angle” and “closed-angle” (or “angle closure”) glaucoma. The angle refers to the area between the iris and cornea, through which fluid must flow to escape via the trabecular meshwork, an area of tissue in the eye located around the base of the cornea. Closed-angle glaucoma can appear suddenly and is often painful; visual loss can progress quickly, but the discomfort often leads patients to seek medical attention before permanent damage occurs. Open-angle, chronic glaucoma tends to progress at a slower rate and patients may not notice they have lost vision until the disease has progressed significantly.

Medical Marijuana Efficacy

Medical marijuana’s primary benefit for glaucoma patients is its effect on intraocular pressure (IOP). In one study, more than 80% of patients who smoked marijuana using an ice-cooled water pipe experienced a reduction in IOP of 16-45%. Another study used cannabinoids contained in medicinal marijuana, and found a signficant drop in IOP in patients who took THC and cannabidiol. A third clinical trial also found that medical marijuana reduces intraocular pressure, as well as blood pressure overall.

Official Research Reports

Dronabinol and retinal hemodynamics in humans. (Plange N, Arend KO, Kaup M, Doehmen B, Adams H, Hendricks S, Cordes A, Huth J, Sponsel WE, Remky A, 2007)

Effect of Sublingual Application of Cannabinoids on Intraocular Pressure: A Pilot Study (Tomida I, Azuara-Blanco A, House H, Flint M, Pertwee RG, Robson PJ, 2006)

Clinical relevance of cannabis tolerance and dependence (Jones RT, Benowitz NL, Herning RI, 1981)

Topical delta 9-tetrahydrocannabinol and aqueous dynamics in glaucoma  (Merritt JC, Perry DD, Russell DN, Jones BF, 1981)

Effect of marijuana on intraocular and blood pressure in glaucoma (Merritt JC, Crawford WJ, Alexander PC, Anduze AL, Gelbart SS, 1980)

Effects of tetrahydrocannabinol on arterial and intraocular hypertension (Crawford WJ, Merritt JC, 1979)

Effect of delta-9-tetrahydrocannabinol on intraocular pressure in humans. (Cooler P, Gregg JM, 1977)

Marijuana smoking and reduced pressure in human eyes: drug action or epiphenomenon? (Flom MC, Adams AJ, Jones RT, 1975)

Marihuana smoking and intraocular pressure (Hepler RS, Frank IR, 1971)

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