To be granted an official license, applicants must submit detailed plans of their proposed production site and yield to government officials.
To qualify for a license, individuals must be Zimbabwe citizens or residents, or, alternatively, be granted a waiver issued by the minister.
Those previously convicted of drug offences will not be blocked from applying.
Lesotho became Africa’s first State to legalise cannabis for medical production last year.
One of the primary motivators for legalisation is the desire to bring in new revenues for the Zimbabwean economy.
Discussing the proposals last year, Obert Mpofu, the then investment minister, said a Canadian firm had applied to the government for a permit to produce the drug in planned special economic zones designed to lure foreign investors.